effects of modulators of glutathione homeostasis on phenytoin embryopathy in mice.
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effects of modulators of glutathione homeostasis on phenytoin embryopathy in mice.

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Published .
Written in English


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Pagination74 leaves
Number of Pages74
ID Numbers
Open LibraryOL19470573M

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Pergamon Press pic EFFECT OF MODULATORS OF GLUTATHIONE SYNTHESIS ON THE HEPATOTOXICITY OF 2-METHYLFURAN VlJAYALAKSHMI RAVINDRANATH* and MICHAEL R. BOYD Program Development Research Group, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, by: Vina J, Perez C, Furukawa T, Palacin M, Vina JR: Effect of oral glutathione on hepatic glutathione levels in rats and mice. Br J Nutr –, PubMed CrossRef Google Scholar Cited by:   Glutathione plays a central role in the maintenance of tissue antioxidant defenses and in the regulation of redox sensitive signal transduction. In muscle cells, the level and redox status of GSH regulates activity of the redox sensitive transcription factor NF-κB. Physical exercise may cause oxidation of GSH in tissues such as the blood, skeletal muscle and by:   Glutathione (GSH) is critical to fight against oxidative stress. Its very low bioavailability limits the interest of a supplementation. The purpose of this study was to compare the bioavailability, the effect on oxidative stress markers and the safety of a new sublingual form of GSH with two commonly used dietary supplements, N-acetylcysteine (NAC) and oral by:

GCS catalyzes the first step reaction in de novo glutathione synthesis to form γ-glutamylcystein from cysteine and glutamate. GCS is composed of heavy and light subunits, namely GCS-HS and GCS-LS. As summarized in Table 2, a single injection of LPS resulted in an increase (57 ± 13%) in GCS activity in midbrain compared with saline-injected animals (P Cited by: The glutathione–ascorbate cycle is responsible for detoxification of O 2 − produced during photosynthesis or aerobic respiration (Figure 2; Noctor, ).H 2 O 2 generated directly or after conversion by superoxide dismutases from other ROS species is initially degraded to H 2 O by ascorbate peroxidases (APXs) using ascorbate as electron donor. The resulting short-lived radical Cited by:   Glutathione has also emerged a key modulator of xenobiotic toxicity, most notably the persistent organic pollutants which are associated with many diseases of impaired metabolic activity, including diabetes, obesity, and cardiovascular disease. γ-glutamyl transpeptidase (GGT), an enzyme critical to the catabolism of GSH and its conjugates.   Besides involvement in ascorbate-glutathione cycle, glutathione is also critical for the detoxification of xenobiotics, sequestration of heavy metals and other processes involved in environmental stress by:

Assessment of Glutathione Homeostasis Article (PDF Available) in Methods in molecular biology (Clifton, N.J.) June with 63 Reads How we measure 'reads'.   In the current study, we have used cultured precision human prenatal liver slices to study the effects of the human teratogen phenytoin (diphenylhydantoin; Dilantin) on cell toxicity, glutathione redox status, and steady-state mRNA expression of a panel of oxidative stress-related biomarker by: left soleus muscle total glutathione content, an effect that was interpreted as an index of oxidative stress. Recovery of muscle glutathione level was slow in the post-exercise recovery period. This recovery was remarkably faster in mice supplemented with allopurinol, an inhibitor of the superoxide producing enzyme xanthine oxidase. It was.   The strychnine-insensitive binding of [3 H]glycine to NMDA receptors is most markedly reduced only by GSSG and glutathionesulfonate at a 1-mM and S-alkyl derivatives of glutathione have been significantly less effective (Jenei et al., ).These effects are additive to the inhibition by the glycine co-activatory site antagonists 7-chlorokynurenate and 3-amino-1 Cited by: